Vitamin Replacement Based on Deficiencies

Vitamin D Deficiency

Racial groups with a higher skin pigmentation (African Americans and southern East Indians, for example) have much higher rates of vitamin D deficiency, and therefore require a much more robust vitamin D replacement in a multivitamin. Research studies have consistently shown that these populations require significantly more vitamin D replacement than available in most multivitamin formulations. African Americans consistently need more vitamin D. Additionally, vitamin D deficiency has been associated with worse health outcomes related to prostate cancer, colon cancer, breast cancer, ovarian cancer, COVID-19 and more. VitaCode's Sequence Multivitamins will provide targeted replacement for individuals from racial groups based on population data and trends.

The figure below shows the overall percent of targeted replacement goal for Americans. It shows the vitamin D replacement well below target goal and other vitamins three to four times the goal. This supports Vitacode’s approach to over-replace some vitamins and minerals while leaving out others. Why add more of a vitamin that already has over-replacement?

USDA Vitamin & Mineral Percent of Nutrition Goal

While this table show target vitamin levels across all of the US population, the table for African Americans would look different. Vitamin D levels would be even lower, as well as magnesium, potassium, and folate. Vitamin K, for example, shows good replacement overall for all populations, but African Americans have been shown to more easily form blood clots that can cause strokes, heart attacks, and pulmonary embolisms that can be life threatening. VitaCode choose to leave vitamin K out of its African American Sequence Multivitamins due to this potentially counter-productive tendency. Ideally, a multivitamin should have what you need . . . and not have what you don't need. African Americans do not need extra vitamin K.

Magnesium Deficiency

A recent article in the journal “Open Heart” discussed sub-clinical magnesium deficiency as a major “driver of cardiovascular disease and a public health crisis.” Because certain groups have a higher cardiovascular risk based on race or family history, they should receive more magnesium replacement. In hypertension, for example, magnesium status has a direct effect upon the relaxation capability of vascular smooth muscle cells and the regulation of the cellular placement of other cations important to blood pressure. As a result, nutritional magnesium has both direct and indirect impacts on the regulation of blood pressure and therefore on the occurrence of hypertension. Many patients with hypertension are treated with thiazide and loop diuretics, both of which deplete the body of magnesium, and giving patients with hypertension who are receiving long-term thiazide diuretics oral magnesium supplementation significantly reduces blood pressure. African Americans have documented lower magnesium stores, less consumption as a population, higher hypertension and heart issues, and therefore a greater need. The same studies showed magnesium stores much better in Hispanic-Latino populations, therefore these populations would need less magnesium.

Magnesium has also been shown to decrease the risk of breast cancer as well as slow its progression and/or recurrence. African American women have the highest breast cancer death rate and would benefit from added magnesium. Other studies show Magnesium also decreases colon cancer occurrence and progression.


Lactose Intolerance

One of the major dietary sources of riboflavin (vitamin B2) is milk and related dairy products. With genetically driven lactose intolerance, and related milk avoidance, increased riboflavin replacement in lactose intolerant people is warranted. Riboflavin deficiencies was associated with worse Multiple Sclerosis (MS) outcomes.


These statements have not been evaluated by the Food and Drug Administration. VitaCode's Sequence Multivitamin & Minerals is not intended to diagnose, treat, cure or prevent any disease.

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